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12:16, April 19 Scientists grow human mini-lungs in lab
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10:23, April 19 JAMA Oncology: Urine test can help rule out high-grade prostate cancer with almost 100% accuracy, study shows
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18:00, April 18 Daily Mail: Elderly woman in China gets infected with brain-eating amoeba
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14:19, April 18 Obesity: exercising before breakfast helps you lose weight faster
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10:42, April 18 The Conversation: childhood trauma can cause pathological hoarding
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08:37, April 18 Daily Mail: Satiating food reduces cravings for sweets, nutritionist says
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18:22, April 17 First Armenian-German Conference entitled “Heart Failure Spring School”
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08:38, April 17 Why do kids usually recover from COVID-19 more easily than adults?
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14:37, April 16 Daily Mail: intermittent fasting is not suitable for children and women before their periods
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16:41, April 15 Cell: in carriers of defective BRCA2 gene, sugar consumption increases cancer risk
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15:04, April 15 305 cases of measles recorded in Armenia so far in 2024
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14:38, April 15 Food and Environmental Virology: tea contributes to effective coronavirus control
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12:41, April 15 Daily Mail: vitamin A, B3 and E supplements can be dangerous
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10:56, April 15 Diabetes Care: evening physical activity is good for the heart
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08:27, April 15 Women are more susceptible to blood loss and death during bypass surgery than men, researchers say
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Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration
Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair.
We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to blood from young mice by parabiosis counteracts this regenerative capacity.
The secreted factor, stromal-derived factor 1 (SDF1), is expressed at higher levels in wounded skin of young mice. Genetic deletion of SDF1 in young skin enhanced tissue regeneration. In aged mice, enhancer of zeste homolog 2 (EZH2) and histone H3 lysine 27 trimethylation are recruited to the SDF1 promoter at higher levels, and pharmacologic inhibition of EZH2 restores SDF1 induction and prevents tissue regeneration. Similar age-dependent EZH2-mediated SDF1 suppression occurs in human skin.
Our findings counter the current dogma that tissue function invariably declines with age and suggest new therapeutic strategies in regenerative medicine.
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