Association of body mass index and waist-to-hip ratio with brain structure

January 11, 2019  18:43

Objective To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume.

Methods We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 ± 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained from bioimpedance. Brain images were produced with structural MRI.

Results After adjustment for a range of covariates, higher levels of all obesity measures were related to lower gray matter volume: BMI per 1 SD (β coefficient −4,113, 95% confidence interval [CI] −4,862 to −3,364), WHR (β coefficient −4,272, 95% CI −5,280 to −3,264), and fat mass (β coefficient −4,590, 95% CI −5,386 to −3,793). The combination of overall obesity (BMI ≥30 kg/m2) and central obesity (WHR >0.85 for women, >0.90 for men) was associated with the lowest gray matter compared with that in lean adults. In hypothesis-free testing with a Bonferroni correction, obesity was also related to various regional brain volumes, including caudate, putamen, pallidum, and nucleus accumbens. No associations between obesity and white matter were apparent.

Conclusion The combination of heightened BMI and WHR may be an important risk factor for gray matter atrophy.


Neurology

Follow NEWS.am Medicine on Facebook and Twitter


 
  • Video
 
 
  • Event calendar
 
 
  • Archive
 
  • Most read
 
  • Find us on Facebook
 
  • Poll
Are you aware that in 2027 medical insurance will become mandatory for all Armenian citizens?
I’m aware, and I'm in favor
I’m not aware, and I'm against
I'm aware, but I'm still undecided
I'm not aware, but in principle I'm in favor
I'm not aware, but in principle I'm against
It doesn't matter to me