Scientists find new compounds against sustainable tuberculosis

August 21, 2019  15:16

Scientists from the Ural Federal University together with colleagues from the I. Ya. Postovsky Institute of Organic Synthesis and the Vavilov Institute of General Genetics Russian Academy of Sciences synthesized compounds that can be effective against drug-resistant tuberculosis.

The bacteria Mycobacteriaceae, the causative agents of tuberculosis, learn to defend from the drugs and survive, resulting in resistant strains that can be very difficult to fight. Thus, doctors are forced to use the most toxic drugs, which are dangerous for the cells of the body.

Russian scientists have proposed changing the approach to the treatment of resistant tuberculosis, using imidazotetrazine derivatives as the basis for new drugs.

These derivatives are similar to purines (9H-imidazo [4,5-d] pyrimidines). The synthesized substances are distinguished by the presence of a large number of nitrogen atoms in the structure, which gives them special properties.

Bacteria eventually developed resistance to these compounds, but it differed from resistance to standard antibiotics and developed less frequently than usual.

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