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Vaccine against malignant brain tumors passes first phase of clinical trials

March 25, 2021  14:50

A vaccine against malignant brain tumors (diffuse glioma) has passed the first phase of clinical trials. The vaccine was found to be safe and elicited the desired immune response in tumor tissue, the team said in the journal Nature.

According to Newatlas.com, a few years ago, the team developed an artificial version of the IDH1 protein segment with a mutation characteristic of this type of cancer. This mutation-specific peptide vaccine was able to stop the growth of cancer cells with the IDH1 mutation in mice.

As part of the first phase of human testing, the drug was tested in 33 patients with IDH1 mutated gliomas. They received the peptide vaccine in addition to standard treatment. The immune response was assessed in 30 patients.

In 93% of patients, the immune system showed a specific response to the vaccine. The three-year survival rate after treatment was 84% ​​in fully vaccinated patients; in 63% of patients, the tumor did not progress in the same period of time. At the same time, none of the vaccinated had serious side effects.

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