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Scientists disocver factor affecting COVID-19 severity
Changes in the metabolism of blood plasma and human immune cells affect the body's immune response to the SARS-CoV-2 coronavirus, a new study reported published at Nature Biotechnology.
Scientists at the Institute of Systems Biology, together with colleagues at Washington and Stanford Universities, collected 374 blood samples from 198 patients during the first week after they were diagnosed with COVID-19. Experts have studied 1,387 genes that regulate the metabolic pathways of immune cells, as well as 1,050 blood plasma metabolites.
As it turned out, changes in the activity of metabolites were a factor in the increased severity of the course of coronavirus infection. In addition, single cell sequencing showed that each type of immune cell had its own distinct metabolic signatures.
According to scientists, for each type of cells - T-killers, T-helpers and B-lymphocytes that contribute to the production of antibodies - were characterized by a special metabolic rearrangement.
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