Translational Psychiatry: Keto Diet Reduced Depression in Students by 70%

A small study has shown that following a well-balanced ketogenic diet for at least ten weeks was associated with about a 70% reduction in depressive symptoms among a group of college students.

The findings were published in the journal Translational Psychiatry.

In addition to fewer depressive symptoms — reported both by participants and clinicians — overall student well-being nearly tripled. Cognitive test performance also improved, and all but one participant lost weight. The study involved 16 students who, prior to starting the diet, were receiving treatment in the form of medication, psychological support, or both for major depressive disorder. The results suggest that achieving nutritional ketosis through diet may serve as an effective adjunct therapy for depression and highlight the need for larger clinical trials.

It is important to note that this pilot study did not include a control group that did not follow the keto diet. By comparison, conventional treatments such as medication and counseling typically reduce depressive symptoms by about 50% over a similar timeframe.

“So many people are suffering right now, so it’s very meaningful to offer a potential solution,” said lead author Jeff Volek, professor of human sciences at Ohio State University.

He added that while more scientific evidence is needed, existing findings support considering broader use of a well-formulated ketogenic diet as a complement to traditional depression treatment. Researchers from Ohio State University, together with mental health specialists, designed and conducted this pilot study among young students. Stress, anxiety, and depression are major barriers to academic success, noted co-author Ryan Patel, a psychiatrist at the university’s student counseling service. About 40% of students report experiencing symptoms of depression, and roughly half of them are already receiving some form of treatment.