Monash University drug discovery researchers have found that a natural fat molecule called "lipoxin A4" (LXA4) could significantly reduce inflammation and improve function for diabetic hearts, reports MedicalXpress.

The preclinical study, published in Cardiovascular Diabetology, found that LXA4, which is known for its "calming agent" action in turning off the body's inflammatory response and preventing chronic inflammation, could also serve as a potential new treatment for diabetes-induced heart disease.

Heart conditions like atherosclerosis, heart attacks and heart failure are the leading killers of people with diabetes, driving a growing global health crisis.

Senior author Dr. Chengxue Helena Qin, from the Monash Institute of Pharmaceutical Sciences (MIPS), said chronic inflammation plays a key role in these heart problems, causing ongoing damage to the diabetic heart over time.

"We found that LXA4 could halve inflammation and scar formation, specifically in cases of heart disease induced by diabetes, as seen in the preclinical animal models," Dr. Qin said. "With recent advancements in developing more 'drug-like' LXA4, our findings point to the potential of LXA4-based therapies as a promising new way to manage diabetic heart disease."

Another co-author of the research, Senior Research Fellow at Monash's Department of Diabetes, Dr. Phillip Kantharidis said currently, heart inflammation in diabetic patients is treated the same way as that of other heart disease patients.

"This study opens up the possibility of more targeted and effective treatment possibilities for diabetic heart disease patients when combined with their usual blood sugar management medication," Dr. Kantharidis said.