For many years, transient ischemic attacks (TIAs), commonly called “mini-strokes,” were considered short-lived and without consequences. However, new research shows that the consequences of TIAs can persist longer than previously thought, manifesting themselves in the form of persistent fatigue, writes the medical journal of the American Academy of Neurology.

A recent study published in the journal sheds light on this phenomenon. The study, conducted by Dr. Boris Modrau and his team at Aalborg University Hospital in Denmark, involved 354 people with an average age of 70 who had a mini-stroke.

Participants completed questionnaires about their level of fatigue within the first two weeks of the mini-stroke and again at three, six, and 12 months later.

The study found that 61% of the participants experienced fatigue two weeks after the mini-stroke and 54% experienced fatigue at each of the three other testing time periods at three, six and 12 months.

Participants also had brain scans. Researchers found that the presence of a blot clot on a scan was equal between people with long term fatigue and those without it, so this did not explain the reason for the level of fatigue.

Researchers did find that previous anxiety or depression was twice as common in those participants who reported lasting fatigue, suggesting a possible psychological component to the persistence of this symptom.

These findings dismiss the traditional view of TIA as a transient complication with no long-term consequences. They underscore the importance of monitoring patients for long-term symptoms like fatigue, which can significantly impact quality of life.

Dr. Modrau said that health care providers should recognize and address these symptoms early, as early intervention can reduce the duration of long-term fatigue and help prevent other consequences.

The researchers are urging health care professionals to review post-TIA treatment guidelines to include fatigue assessment and mental health support. By acknowledging the potential for long-term effects, health care providers will be better able to assist patients on their journey to recovery, the study authors say.