Research shows that naringin, a bioflavonoid found in citrus fruits, has potent anti-inflammatory and cardioprotective effects, making it a promising candidate for the prevention of cardiovascular disease.

A recent systematic review published in the journal Nutrients analyzed more than 60 studies on the effects of naringin on the cardiovascular system.

The findings showed that naringin contributes to the restoration of endothelial function, reduces inflammation and oxidative stress, and improves energy metabolism in heart cells. In particular, after administration of naringin, calcium levels in the hearts of diabetic mice were normalized and cellular energy pathways were activated, which indicates the restoration of metabolic dysfunction at the cellular level.

But despite these promising findings, the clinical application of naringin is limited due to its low bioavailability (<5%). This has stimulated the development of new methods to enhance this drug's efficacy, such as liposomal encapsulation.

Therefore, naringin is a promising agent for the prevention of cardiovascular diseases, but further studies and the development of effective delivery methods are needed for its widespread use.