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10:23, April 19 JAMA Oncology: Urine test can help rule out high-grade prostate cancer with almost 100% accuracy, study shows
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18:00, April 18 Daily Mail: Elderly woman in China gets infected with brain-eating amoeba
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14:19, April 18 Obesity: exercising before breakfast helps you lose weight faster
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10:42, April 18 The Conversation: childhood trauma can cause pathological hoarding
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08:37, April 18 Daily Mail: Satiating food reduces cravings for sweets, nutritionist says
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18:22, April 17 First Armenian-German Conference entitled “Heart Failure Spring School”
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08:38, April 17 Why do kids usually recover from COVID-19 more easily than adults?
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14:37, April 16 Daily Mail: intermittent fasting is not suitable for children and women before their periods
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16:41, April 15 Cell: in carriers of defective BRCA2 gene, sugar consumption increases cancer risk
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15:04, April 15 305 cases of measles recorded in Armenia so far in 2024
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14:38, April 15 Food and Environmental Virology: tea contributes to effective coronavirus control
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12:41, April 15 Daily Mail: vitamin A, B3 and E supplements can be dangerous
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10:56, April 15 Diabetes Care: evening physical activity is good for the heart
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08:27, April 15 Women are more susceptible to blood loss and death during bypass surgery than men, researchers say
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18:42, April 13 WHO: Nigeria pioneers revolutionary meningitis vaccine
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Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels
Corneal injuries are common causes of visual impairment worldwide. Accordingly, there is an unmet need for transparent biomaterials that have high adhesion, cohesion, and regenerative properties. Herein, we engineer a highly biocompatible and transparent bioadhesive for corneal reconstruction using a visible light cross-linkable, naturally derived polymer, GelCORE (gel for corneal regeneration).
The physical properties of GelCORE could be finely tuned by changing prepolymer concentration and photocrosslinking time. GelCORE revealed higher tissue adhesion compared to commercial adhesives. Furthermore, in situ photopolymerization of GelCORE facilitated easy delivery to the cornea, allowing for bioadhesive curing precisely according to the required geometry of the defect. In vivo experiments, using a rabbit stromal defect model, showed that bioadhesive could effectively seal corneal defects and induce stromal regeneration and re-epithelialization.
Overall, GelCORE has many advantages including low cost and ease of production and use. This makes GelCORE a promising bioadhesive for corneal repair.
Full article: Science Advances
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