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Scientists have developed a novel drug that could block glioblastoma -- the deadliest form of brain cancer -- from spreading.
The tissues in our bodies are largely made of fluid. It moves around cells and is essential to normal body function. But in some cases, this fluid may be doing more harm than good.
In people who have glioblastoma, this fluid has a much higher pressure, causing it to move fast and forcing cancer cells to spread.
The AMD3100 drug, which has already been used in clinics, was found effective in stopping the inevitable cancer cell spread, the researchers said. The researchers tested the AMD3100 drug and found that it could block the rapid movement of the brain's interstitial fluid flow and the spread of cancer cells.
"I am hopeful that since the drug that we used to block flow stimulation is currently used in patients that maybe clinicians when they do consider using convection-enhanced delivery, will combine that with this drug," said lead author Chase Cornelison, a postdoctoral researcher at the Virginia Polytechnic Institute and State University.
