The number of deadly overdoses from fentanyl surged between 2016 and 2021, according to a disquieting new report from the U.S. Centers for Disease Control and Prevention.

The report found that 69,943 died of a fentanyl-induced overdose in 2021 at a rate of 21.6. That is up considerably from 2016, when 18,499 died of an overdose from fentanyl at a rate of 5.7.

The report found an increase in deadly overdose from several other drugs as well.

“The age-adjusted rate of drug overdose deaths involving fentanyl more than tripled over the study period, from 5.7 per 100,000 standard population in 2016 to 21.6 in 2021, with a 55.0% increase from 2019 (11.2) to 2020 (17.4), and a 24.1% increase from 2020 to 2021 (21.6). The rate of drug overdose deaths involving methamphetamine more than quadrupled, from 2.1 in 2016 to 9.6 in 2021,” the CDC reported. The rate of drug overdose deaths involving cocaine more than doubled, from 3.5 in 2016 to 7.9 per 100,000 in 2021. The rate of drug overdose deaths involving heroin decreased by 40.8%, from 4.9 in 2016 to 2.9 in 2021, although this decrease was not statistically significant. The rate of drug overdose deaths involving oxycodone decreased 21.0%, from 1.9 in 2016 to 1.5 in 2021.”

“In 2021, the age-adjusted rate of drug overdose deaths was highest for deaths involving fentanyl (21.6 per 100,000 standard population), followed by methamphetamine (9.6), cocaine (7.9), heroin (2.9), and oxycodone (1.5). Patterns were similar when stratified by sex,” the report continued.