Scientists from the Chinese Academy of Sciences have reported the creation of aging-resistant mesenchymal progenitor cells (SRC). In the experiment, they reversed age-related changes in macaques, the closest biological relatives of humans. The results of the study were published in the journal Cell.

With age, the body's cell renewal mechanisms begin to work less efficiently: new cells are formed more slowly, and old cells are not removed in a timely manner. This leads to a gradual decline in organ function, inflammation, metabolic disorders, and other signs of aging.

SRC cells have been found to be able to intervene in this process. For 44 weeks, elderly macaques, whose age corresponded to approximately 60-70 human years, were injected with SRC every two weeks. As a result, no side effects were observed in the animals: there was no increase in temperature, no inflammation, and no decrease in body weight.

The experiments showed that rejuvenation affected 10 body systems and 61 tissue types. The effect of SRC cells also weakened the signs of osteoporosis and fibrosis, reduced inflammation, and improved memory. Reproductive function was also restored: sperm production in macaques became more active. At the cellular level, scientists noted DNA strengthening, reduced oxidative stress, and restored protein function.

The mechanism of action of SRC is associated with the release of exosomes — microscopic vesicles containing proteins and RNA molecules. These “capsules” transmit signals to cells that suppress inflammation and stimulate recovery.

The safety of the therapy has also been proven: none of the monkeys developed tumors. According to the authors, if the technology is adapted for humans, it could slow the progression of age-related diseases, improve quality of life in old age, and even restore reproductive function.