Spanish woman María Branyas passed away last year at the age of 117. Analysis of her genome revealed that her biological age was significantly younger than her chronological one.

Experts have long been interested in supercentenarians—people who live to at least 110—since the secret of their longevity may hold the key to healthy aging.

Shortly before her death in August 2024, María Branyas agreed to help a group of Spanish scientists investigate this mystery, reports Euronews. At the age of 116, specialists collected samples of her blood, saliva, urine, and stool to analyze her microbiome (the collection of microbes inhabiting the human body) and compare the results with those of people of similar age.

Branyas showed biomarkers of advanced age, including shortened telomeres—a key indicator of cellular aging. Her body also contained a large number of B-cells, which tend to accumulate with age.

Researchers also identified clonal hematopoiesis—a process in which hematopoietic stem cells produce blood cells carrying the same mutation, something commonly observed in the elderly.

At the same time, Branyas had a low level of inflammation in her body, a “rejuvenated” gut, and a surprisingly youthful epigenome.

The scientists described Branyas as an “exceptional individual,” noting that her genetic code contained unusual variations that protected her from common health problems, including heart disease, diabetes, and neurodegenerative disorders such as Alzheimer’s and Parkinson’s.

As the researchers emphasized in their article published in Cell Reports Medicine, their findings provide “a fresh perspective on the biology of human aging,” highlighting biomarkers of a healthy lifestyle and possible strategies to extend life.

Although Branyas’ genetics clearly played a significant role in her longevity, the researchers also tried to determine which of her habits and lifestyle choices contributed to her reaching the age of 117.

The supercentenarian consumed up to three yogurts daily, which scientists believe may have supported gut health and helped maintain body weight. She followed a Mediterranean diet and healthy sleep patterns, remained physically active, and overall enjoyed good mental health.