An international team of scientists has studied the capture of magnetically controlled capsules by a magnetic field source.
Remote control of magnetically controlled capsules is a promising approach to targeted drug delivery, according to an article by scientists published in the journal Molecules. The international group also includes scientists from N.G. Chernyshevsky Saratov National Research State University.
According to the scientists, targeted delivery is one of the main methods of reducing the side effects of drug therapy, in which the active substance is accumulated directly in the place needed for treatment. Magnetically controlled capsules can also be used to detect and sort tumor cells. The published work showed the possibility of capturing and sorting tumor cells trapped inside magnetic capsules.
In their work, the scientists demonstrated the dependence of the number of captured capsules on their size, on the loading of magnetic nanoparticles, and on the rate of suspension flow. The scientists also evaluated the possibility of magnetic capture of cells containing magnetic capsules in the flow and then evaluated the integrity of cell membranes.
According to them, the results obtained can be used not only to determine optimal fusion parameters, but also in calculations to determine the concentration of the drug to be delivered. Knowing the parameters of the blood vessel, magnet and magnetic carriers, it is possible to estimate how much substance can be delivered and accumulated in a certain place of the body.
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