Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections

October 3, 2018 23:40

Question Does increased daily water intake prevent cystitis in premenopausal women experiencing recurrent cystitis who drink low volumes of total fluid daily?

Findings In this randomized clinical trial of 140 premenopausal women experiencing recurrent cystitis who report drinking less than 1.5 L of total fluid daily, cystitis episodes were significantly less frequent in women who drank more water for 12 months compared with women who maintained their usual fluid intake.

Meaning Increasing daily water intake protects against recurrent cystitis in premenopausal women experiencing recurrent cystitis who drink low volumes of total fluid daily.

Importance Increased hydration is often recommended as a preventive measure for women with recurrent cystitis, but supportive data are sparse.

Objective To assess the efficacy of increased daily water intake on the frequency of recurrent cystitis in premenopausal women.

Design, Setting, and Participants Randomized, open-label, controlled, 12-month trial at a clinical research center (years 2013-2016). Among 163 healthy women with recurrent cystitis (≥3 episodes in past year) drinking less than 1.5 L of fluid daily assessed for eligibility, 23 were excluded and 140 assigned to water or control group. Assessments of daily fluid intake, urinary hydration, and cystitis symptoms were performed at baseline, 6- and 12-month visits, and monthly telephone calls.

Interventions Participants were randomly assigned to drink, in addition to their usual fluid intake, 1.5 L of water daily (water group) or no additional fluids (control group) for 12 months.

Main Outcomes and Measures Primary outcome measure was frequency of recurrent cystitis over 12 months. Secondary outcomes were number of antimicrobial regimens used, mean time interval between cystitis episodes, and 24-hour urinary hydration measurements.

Conclusions and Relevance Increased water intake is an effective antimicrobial-sparing strategy to prevent recurrent cystitis in premenopausal women at high risk for recurrence who drink low volumes of fluid daily.