Multivascular networks and functional intravascular topologies within biocompatible hydrogels

May 4, 2019  12:07

Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study.

We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves.

We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.

Full article: Science

Follow NEWS.am Medicine on Facebook and Twitter

loading...

  • Video
 
 
 
  • Event calendar
 
  • Archive
 
  • Most read
 
  • Find us on Facebook
 
  • Poll
How much money are you ready to donate each month to help infertile couples?
2500 AMD
5000 AMD
More than 10 000 AMD
Not ready to donate