Chimera mice in whose brain human stem cells are transplanted can help in the study of Alzheimer’s, Neuron reported.
The study was conducted by a team of scientists led by Mathew Blurton-Jones from the University of California, Irvine.
It was difficult for specialists to study human microglia affected by Alzheimer's disease. Microglia plays an important role in the formation of the brain. As part of the study, scientists introduced human-induced pluripotent stem cells into the brain of genetically modified mice, which can turn into a cell of any tissue or organ.
After several months, 80% of the microglia of GM mice consisted of human cells. This allowed scientists to track the response of microglia to Alzheimer's provoking amyloid plaques.
According to scientists, GM mice with ‘human’ microglia can help in the study of treatment for stroke, Parkinson's disease, as well as traumatic brain injuries.