Nature Communications: Psoriasis is caused by gene mutations, study finds

March 26, 2024  13:21

Scientists from The Australian National University (ANU)  have discovered a mutation in the IKBKB gene, which is responsible for causing psoriasis—a chronic inflammatory skin disease that causes patients to develop red, scaly, and itchy patches across their body.

The results of the research were published in Nature Communications.

The researchers noted that patients with psoriasis who have two copies of the mutated IKBKB gene may develop psoriatic arthritis. It is a chronic progressive disease of the vessels, which is accompanied by a rash.

According to the scientists, the mutation in IKBKB causes a malfunction of an immune component known as the regulatory T-cell. They suppress the immune reaction of other cells. This important system of "self-control" is necessary for the prevention of excessive reactions, including autoimmune reactions.

A change in the normal function of IKBKB in the body causes inflammation and prompts the immune system to attack healthy cells, mistakenly perceiving them as threats. It is the cause of many autoimmune diseases, including psoriasis.

The authors of the study noted that their work may further contribute to the creation of new and more effective methods of psoriasis therapy.

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