Moderate Wine Consumption May Slow Biological Aging in Men

A new study published in the International Journal of Public Health suggests that moderate wine consumption may be associated with slower biological aging in men.

The research is based on data from the large Italian Moli-sani project, which included more than 20,000 participants. Scientists assessed not just chronological age, but so-called biological age—a measure reflecting the condition of the body at the level of cells, tissues, and systems. It was calculated using artificial intelligence based on dozens of biomarkers, including hormones, lipids, and inflammation markers.

The results showed that men who consumed wine in moderation (about one to two glasses per day) had, on average, a lower biological age than those who did not drink at all. The most pronounced effect was observed at a consumption level of around 150–200 ml per day, where the difference could amount to several months of “rejuvenation.”

The study also identified a U-shaped relationship: both very low and excessive wine consumption showed no benefit, while alcohol abuse was associated with accelerated aging.

Interestingly, no similar association was found in women. However, a statistically significant difference between sexes could not be firmly established, so the researchers urge caution in interpreting these findings.

The authors emphasize that the positive effect is likely not due to alcohol itself, but rather to compounds found specifically in wine—particularly polyphenols, which are known for their anti-inflammatory and antioxidant properties. Overall ethanol consumption (including other alcoholic beverages) did not show a similar link to slower aging.

The researchers also stress that the study is observational and does not prove causation. Moreover, moderate drinkers tended to have healthier lifestyles overall—they were more physically active, had normal body weight, and fewer chronic conditions—which may have influenced the results, even though these factors were accounted for in the analysis.

In conclusion, the study adds to the evidence that not only the amount of alcohol but also its type—and overall lifestyle—matter. However, further long-term research is needed before drawing definitive conclusions about the effects of wine on aging.

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