Researchers find out risks of artificial pulmonary ventilation of premature babies

Many premature infants need mechanical ventilation to breathe. However, prolonged ventilation can lead to problems like respiratory diseases or ventilation-induced injury, writes the Biophysical Society.

Jonas Naumann and Mareike Zink study the physics of mechanical stress from ventilation at Leipzig University, in Leipzig, Germany and discovered some of the mechanisms that explain why premature lungs are especially sensitive to stress.

When you breathe normally, your diaphragm and the muscles between ribs create a negative pressure inside the lung. "But when you are undergoing mechanical ventilation, you are creating hydrostatic overpressure. And the forces which are acting during mechanical ventilation are completely different than during normal breathing. And this is probably causing some kind of damage to the cells," Zink explained.

Using lung tissue from fetal and adult rats, the researchers together with collaborators from the Division of Neonatology, University Clinic Leipzig, used varying amounts of tension with rest phases in between, similar to the actions that occur within the lung during mechanical ventilation. 

Even with a little pressure, the premature rat lung tissue showed characteristics of being both elastic and viscous. This means the lung tissue changed its shape and responded to stress in a way that wasn't normal. Moreover, they found that "the fetal lung is much stiffer than the adult lung under deformation," said Naumann.

The researchers also found that changes in pressure affected the activity of two channels involved in sodium transport-;the epithelial sodium channel and the sodium-potassium ion pump in the cells of lung alveoli. This disruption in the normal function of these transporters could explain why mechanical ventilation has negative effects on the infant's lungs.

"This may be the reason why lung fluid cannot get absorbed that well into the circulation after the preterm births," Naumann explained.

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